What exactly is paracetamol

　　Paracetamol,with product names such as Baifeining,Bilitong,Tylenol,Acetaminophen,etc.The international non proprietary drug name of this product is Paracetamol.It is a commonly used non anti-inflammatory,antipyretic,and analgesic drug.Its antipyretic effect is similar to that of aspirin,with weak analgesic effect and no anti-inflammatory or anti rheumatic effect.It is a good variety of acetanilide drugs.Especially suitable for patients who cannot use carboxylic acid drugs.Used for symptoms such as colds and toothache.Acetaminophenol is also an intermediate in organic synthesis,a stabilizer for hydrogen peroxide,and a photographic chemical.

　　Pharmacodynamics:This product is an acetanilide type antipyretic and analgesic drug.By inhibiting cyclooxygenase,selectively inhibiting the synthesis of prostaglandins in the hypothalamic thermoregulation center,leading to peripheral vascular dilation and sweating to achieve the antipyretic effect,whose antipyretic effect intensity is similar to aspirin;By inhibiting the synthesis and release of prostaglandins and other substances,it increases the pain threshold and has an analgesic effect.It belongs to the category of peripheral analgesics,with weaker effects than aspirin,and is only effective for mild to moderate pain.This product has no significant anti-inflammatory effect.

　　Pharmacokinetics:After oral administration,absorption from the gastrointestinal tract is rapid and complete(taking medication after a high carbohydrate diet may reduce absorption),and after absorption,it is evenly distributed in body fluids,with about 25%binding to plasma proteins.At low doses(blood drug concentration<60μThe binding rate between g/ml and protein is not significant,while in large or toxic amounts,the binding rate is higher,up to 43%.90-95%of this product is metabolized in the liver and mainly binds to glucuronic acid,sulfuric acid,and cysteine.Intermediate metabolites have toxic effects on the liver.half lifeβIt usually lasts for 1-4 hours(average of 2 hours),and remains unchanged during renal insufficiency.However,it may be prolonged in some liver disease patients,elderly and newborns,and shortened in children.After oral administration,the peak blood drug concentration can be reached within 0.5-2 hours,and the blood drug concentration is 5-20 when the dose is below 650mgμG/ml,the duration of action is 3-4 hours.During lactation,women take 650mg of this product,with a concentration of 10-15 in milk for 1-2 hoursμG/ml;half lifeβ1.35-3.5 hours.This product is mainly excreted from the kidneys in the form of binding with glucuronic acid,and approximately 3%is excreted in the urine in its original form within 24 hours.

　　Suitable for relieving mild to moderate pain,such as fever,headache,joint pain,neuralgia,migraine,dysmenorrhea,etc.caused by colds.This product cannot be used as a substitute for aspirin or other non-steroidal anti-inflammatory drugs in the treatment of various types of arthritis,as it can only alleviate symptoms and has no or minimal anti-inflammatory effects,and cannot eliminate redness,swelling,or movement disorders caused by arthritis.But this product can be used in cases of allergy,intolerance,or unsuitability to aspirin,such as patients with chickenpox,hemophilia,and other hemorrhagic diseases(including those treated with anticoagulant therapy),as well as peptic ulcers,gastritis,etc.When using this product,other therapies must also be used when necessary to relieve the cause of pain or fever.